Plasma protein binding of fruquintinib is approximately 95%.%
Metabolism
Fruquintinib is primarily eliminated by CYP450 and non-CYP450 (i.e., sulfation and glucuronidation) metabolism. CYP3A and to a lesser extent CYP2C8, CYP2C9, and CYP2C19 are the CYP450 enzymes involved in fruquintinib metabolism.
Elimination
42hr
Excretion
A previous study reported that following administration of 5 mg of radiolabeled fruquintinib, approximately 60% of the dose was recovered in urine (0.50% unchanged) and 30% was recovered in feces (5.34% unchanged), with the remaining radioactivity excreted as metabolites.
Formula
C21H19N3O5
Molar Mass
393.399
Drug Class
Antineoplastic
Volume of Distribution
C21H19N3O5
🤰 Pregnancy Category Information
Category: AU: D
Drugs which have caused, are suspected to have caused, or may be expected to cause an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.
