📊 Estimates Zelapar Dialyzability By Different_Modalities

Zelapar

Complete Drug Information

Drug Name

Zelapar

Trade Names

Eldepryl, Emsam

Pregnancy Category

AU: B2

Bioavailability

Oral: 4–10%ODT: ~5–8× oralTransdermal: 75%

Routes of Administration

Oral, buccal, transdermal

Protein Binding

85–90%%

Metabolism

Liver, other tissues (CYP2B6, CYP2C19, others)

Elimination

Oral:• S (single): 1.2–3.5 h• S (multi): 7.7–9.7 h• DMS (single): 2.2–3.8 h• DMS (multi): 9.5 h• L-MA: 14–21 h• L-A: 16–18 hODT:• S (single): 1.3 h• S (multi): 10 hPatch:• S: 20 h

Excretion

Urine (87%):• L-MA: 20–63%• L-A: 9–26%• DMS: 1%• S: 0.01–0.03%Feces: 15%

Formula

C13H17N

Molar Mass

187.286

Onset of Action

≤1 hour

Duration of Action

2–3 days

Drug Class

Monoamine oxidase inhibitor; Catecholaminergic activity enhancer; Norepinephrine releasing agent; Antiparkinsonian; Antidepressant

Volume of Distribution

C13H17N

🤰 Pregnancy Category Information

Category: AU: B2

Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus. Animal studies are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage.