📊 Estimates modafinil Dialyzability By Different_Modalities

modafinil

Complete Drug Information

Drug Name

modafinil

Trade Names

Provigil

Pregnancy Category

AU: D

Bioavailability

40–65% (based on urinary excretion)

Routes of Administration

Oral (tablets)

Protein Binding

~60% (mainly to albumin)%

Metabolism

Liver (amide hydrolysis, S-oxidation, aromatic ring hydroxylation, glucuronide conjugation; CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 involved)

Elimination

Modafinil: 12–15 hArmodafinil: 10–17 hEsmodafinil: 3–5 h

Excretion

Urine: 80% (≤10% as modafinil, 35–51% as modafinil acid)Feces: 1.0%

Formula

C15H15NO2S

Molar Mass

273.35

Onset of Action

2–4 hours

Duration of Action

11.5 h

Drug Class

Stimulant; Dopamine reuptake inhibitor; Wakefulness-promoting agent

Volume of Distribution

0.9 L/kg

🤰 Pregnancy Category Information

Category: AU: D

Drugs which have caused, are suspected to have caused, or may be expected to cause an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.