📊 Estimates Methotrexate Dialyzability By Different_Modalities

Methotrexate

Complete Drug Information

Drug Name

Methotrexate

Trade Names

Trexall, Rheumatrex, Otrexup

Pregnancy Category

AU: D

Bioavailability

60% at lower doses, less at higher doses.

Routes of Administration

Oral, intravenous, intramuscular, subcutaneous, intrathecal

Protein Binding

35–50% (parent drug), 91–93% (7-hydroxymethotrexate)%

Metabolism

Hepatic and intracellular

Elimination

3–10 hours (lower doses), 8–15 hours (higher doses)

Excretion

Urine (80–100%), feces (small amounts)

Formula

C20H22N8O5

Molar Mass

454.447

Volume of Distribution

0.4 L/kg

🤰 Pregnancy Category Information

Category: AU: D

Drugs which have caused, are suspected to have caused, or may be expected to cause an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.