📊 Estimates ketamine Dialyzability By Different_Modalities

ketamine

Complete Drug Information

Drug Name

ketamine

Trade Names

Ketalar

Pregnancy Category

AU: B3

Bioavailability

Intravenous: 100% Intramuscular: 93% Epidural: 77% Intranasal: 45–50% Sublingual: 24–30% Rectal: 25–30% By mouth: 16–20%

Routes of Administration

Any

Protein Binding

23–47%%

Metabolism

Liver, intestine (oral): Major: CYP3A4, CYP2B6

Elimination

Ketamine: 2.5–3 hours Norketamine: 12 hours

Excretion

Urine: 91% Feces: 3%

Formula

C13H16ClNO

Molar Mass

237.73

Onset of Action

1–5 min

Duration of Action

0.5–2 h

Melting Point

92 °C

Drug Class

NMDA receptor antagonist; general anesthetic; dissociative hallucinogen; analgesic; antidepressant

Volume of Distribution

4 L/kg

🤰 Pregnancy Category Information

Category: AU: B3

Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus. Animal studies have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.