psilocybine  - Drug Details
📊 Estimates psilocybine  Dialyzability By Different_Modalities

psilocybine 

Complete Drug Information

Drug Name
psilocybine 
Bioavailability
Oral: 52.7 ± 20.4% (as psilocin) (n=3)
Routes of Administration
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Protein Binding
66%%
Metabolism
Liver, other tissues:• Dephosphorylation (ALPTooltip alkaline phosphatase)• Demethylation and deamination (MAOTooltip monoamine oxidase)• Oxidation (ALDHTooltip aldehyde dehydrogenase)• Glucuronidation (UGTs)
Elimination
Oral (as psilocin): 2.1–4.7 h (range 1.2–18.6 h)IVTooltip Intravenous administration (as psilocin): 1.2 h (range 1.8–4.5 h)
Excretion
Urine (mainly as psilocin-O-glucuronide, 2–4% as unchanged psilocin)
Formula
C12H17N2O4P
Molar Mass
284.252
Onset of Action
0.5–0.8 h
Duration of Action
4–6 h
Melting Point
220–228 °C
Drug Class
Serotonergic psychedelic; Hallucinogen; Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist
Volume of Distribution
C12H17N2O4P