📊 Estimates propranolol Dialyzability By Different_Modalities

propranolol

Complete Drug Information

Drug Name

propranolol

Trade Names

Inderal

Pregnancy Category

AU: C

Bioavailability

Oral: 25%Sublingual: 63%Intranasal: ~100%

Routes of Administration

Oral, sublingual, intranasal, rectal, intravenous

Protein Binding

90% (albumin and α1-acid glycoprotein)%

Metabolism

Liver (extensive) CYP1A2, CYP2D6; minor: CYP2C19, CYP3A4; aromatic hydroxylation (mainly 4-hydroxylation), N-dealkylation, side-chain oxidation, glucuronidation

Elimination

~4 hours (range 3–8 hours)

Excretion

Urine: 91%

Formula

C16H21NO2

Molar Mass

259.349

Duration of Action

Up to 12 hours

Melting Point

96 °C

Drug Class

Beta blocker

Volume of Distribution

4 L/kg

🤰 Pregnancy Category Information

Category: AU: C

Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible.