📊 Estimates Progestasert Dialyzability By Different_Modalities

Progestasert

Complete Drug Information

Drug Name

Progestasert

Trade Names

Prometrium, Utrogestan, Endometrin

Bioavailability

Oral: <2.4%Vaginal (micronized insert): 4–8%

Routes of Administration

Oral, sublingual, topical, vaginal, rectal, intramuscular, subcutaneous, intrauterine

Protein Binding

98–99%:• Albumin: 80%• CBGTooltip Corticosteroid-binding globulin: 18%• SHBGTooltip Sex hormone-binding globulin: <1%• Free: 1–2%%

Metabolism

Mainly liver:• 5α- and 5β-reductase• 3α-Tooltip 3α-Hydroxysteroid dehydrogenase and 3β-HSDTooltip 3β-Hydroxysteroid dehydrogenase• 20α-Tooltip 20α-Hydroxysteroid dehydrogenase and 20β-HSDTooltip 20β-Hydroxysteroid dehydrogenase• Conjugation• 17α-Hydroxylase• 21-Hydroxylase• CYPsTooltip CYP (e.g., CYP3A4)

Elimination

• Oral: 5 hours (with food)* Sublingual: 6–7 hours• Vaginal: 14–50 hours• Topical: 30–40 hours• IM: 20–28 hours• SC: 13–18 hours• IVTooltip Intravenous injection: 3–90 minutes

Excretion

Bile and urine

Formula

C21H30O2

Molar Mass

314.469

Melting Point

126 °C

Drug Class

Progestogen; Antimineralocorticoid; Neurosteroid

Volume of Distribution

C21H30O2