Extensively absorbed from the GI tract, but extensive first-pass metabolism in the liver
Routes of Administration
Oral
Protein Binding
93–95%%
Metabolism
Extensive, liver (mostly CYP2D6-mediated)
Elimination
21 hours
Excretion
Kidney (64%; 2% unchanged and 62% as metabolites), faecal (36%; <1% unchanged)
Formula
C19H20FNO3
Molar Mass
329.371
Drug Class
Selective serotonin reuptake inhibitor (SSRI)
Volume of Distribution
C19H20FNO3
🤰 Pregnancy Category Information
Category: AU: D
Drugs which have caused, are suspected to have caused, or may be expected to cause an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.
