nicotine

Complete Drug Information

Drug Name

nicotine

Trade Names

Nicorette

Bioavailability

Inhalation: 80–90% Intranasal: 60–80% Transdermal: 68–100%

Routes of Administration

Inhalation, insufflation, oral, buccal, sublingual, rectal, transdermal, ophthmalmic

Protein Binding

<5%%

Metabolism

Primarily hepatic: CYP2A6, CYP2B6, FMO3, others

Elimination

1–2 hours; 16–19 hours cotinine (range is 10–27 hours)

Excretion

Renal, urine pH-dependent; 10–20% (gum), 30% (inhaled); 10–30% (intranasal)

Formula

C10H14N2

Molar Mass

162.236

Melting Point

−79 °C

Drug Class

Nicotinic acetylcholine receptor agonist; Stimulant; Nootropic; Euphoriant

Volume of Distribution

C10H14N2