Critical Pharmacodynamic Warning

artemisinin weakly inhibits the 2B6 metabolic pathway.

When patients take artemisinin concurrently with drugs metabolized by 2B6, the risk of adverse effects may significantly increase. This interaction affects drug clearance and systemic exposure, potentially leading to toxicity or reduced therapeutic efficacy.

Clinical Impact: As a weak inhibitor, artemisinin can alter the metabolism of substrate drugs, requiring careful monitoring and potential dose adjustments.

Clinical Overview for artemisinin

This page outlines known interaction pathways involving artemisinin, focusing primarily on its profile as a Weak inhibitor affecting the 2B6 pathway.

Enzyme Interaction Profile

artemisinin demonstrates weak inhibitor potency against 2B6. This level of inhibition causes ≥1.25-fold but <2-fold increase in AUC of substrate drugs.

Inhibitor

A substance that slows down or prevents an enzyme from metabolizing a drug. Inhibitors can lead to increased drug concentrations in the body, potentially causing toxicity or enhanced therapeutic effects.

Clinical Example: artemisinin weakly inhibits 2B6

Inducer

A substance that speeds up enzyme activity, causing drugs to be cleared from the body faster. Inducers can reduce drug effectiveness by lowering concentrations below therapeutic levels.

Known Inducers: carbamazepine
Interaction Details
Drug Name artemisinin
Affected Enzyme 2B6
Inhibitor Strength Weak inhibitor Low Severity
Inducers carbamazepine
Inhibitors thiotepa
Clinical Recommendations

Generally safe for co-administration. Routine monitoring recommended.

Monitoring Parameters:
  • Therapeutic drug levels
  • Adverse effect monitoring
  • Clinical response assessment
Dose Considerations:
  • Consider dose reduction
  • Evaluate alternative therapies
  • Adjust based on response
Quick Facts
Interaction ID
12542
Primary Pathway
2B6
Interaction Type
Enzyme Inhibition
Clinical Phase
Low Severity
Clinical Significance

Minor clinical significance. Routine monitoring sufficient.

Information Sources
  • FDA Drug Interaction Database
  • Clinical Pharmacology Guidelines
  • Pharmaceutical Labeling Information
  • Published Clinical Studies
Last updated: June 15, 2026
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