DESCRIPTION
Sucralfate-A basic aluminum complex of sulfated sucrose. Oxetacaine-Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain.
CATEGORIES
Sucralfate-Antacids, Antireflux Agents & Antiulcerants . Oxetacaine-Anaesthetics- Local & General.
CHEMICAL FORMULA
Sucralfate-C11H28Al8O51S8. Oxetacaine-C28H41N3O3.
COMPOSITION
Sucralfate 1000 mg + Oxetacaine 20 mg
INDICATION
Sucralfate-For the short-term treatment (up to 8 weeks) of active duodenal ulcer, as well as maintenance therapy for duodenal ulcer patients at reduced dosage (1 gram twice a day) after healing of acute ulcers. Also used for the short-term treatment of gastric ulcer. Oxetacaine-Unlike most local anesthetics, oxetacaine is active even in strongly acidic conditions.
PHARMACODYNAMICS
Sucralfate-Sucralfate is a prescription medication used to treat peptic ulcers. The current clinical uses of sucralfate are limited. It is effective for the healing of duodenal ulcers, but it is not frequently used for this since more effective drugs (e.g. proton pump inhibitors) have been developed. Although the
MECHANISM
of sucralfate’s ability to accelerate healing of duodenal ulcers remains to be fully defined, it is known that it exerts its effect through a local, rather than systemic, action. Chemically, sucralfate is a complex of the disaccharide sugar, sucrose, combined with sulfate and aluminum. In acidic solutions (e.g. gastric acid) it forms a thick paste that has a strong negative charge.
No Information
ABSORPTION
Sucralfate- Minimally absorbed from the gastrointestinal tract (up to 5% of the disaccharide component and less than 0.02% of aluminum).
METABOLISM
Sucralfate-GI; liver: unknown.
ELIMINATION
Sucralfate-The small amounts of the sulfated disaccharide that are absorbed are excreted primarily in the urine.
HALF LIFE
Sucralfate- unknown.
TOXICITY
Sucralfate- Acute oral toxicity (LD50) in mice is >8000 mg/kg. There is limited experience in humans with overdosage of sucralfate. Sucralfate is only minimally absorbed from the gastrointestinal tract and thus risks associated with acute overdosage should be minimal. In rare reports describing sucralfate overdose, most patients remained asymptomatic.
FOOD INTERACTIONS
avoid alcohol.
SIDE EFFECTS
Sucralfate-Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.