trazodone hydrochloride.txt CLINICAL USE Antidepressant DOSE IN NORMAL RENAL FUNCTION Depression: 100–300 mg daily; maximum 600 mg daily in divided doses for hospital patients Anxiety: 75–300 mg daily PHARMACOKINETICS Molecular weight                           : 408.3 %Protein binding                           : 89–95 %Excreted unchanged in urine     : <5 Volume of distribution (L/kg)       : 1–2 half-life – normal/ESRD (hrs)      : 5–13/ – DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function. Start with small doses and increase gradually <10           : Start with small doses and increase gradually DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                : Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     : Unlikely to be dialysed. Dose as in GFR <10 mL/min HDF/high flux   : Unknown dialysability. Dose as in GFR <10 mL/min CAV/VVHD      : Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Alcohol: increased sedative effects Antidepressants: avoid concomitant use with MAOIs and moclobemide Anti-epileptics: antagonism of anticonvulsant effect Antimalarials: manufacturer advises avoid concomitant use with artemether and lumefantrine Sibutramine: increased risk of CNS toxicity – avoid concomitant use ADMINISTRATION Reconstition – Route Oral Rate of Administration – Comments – OTHER INFORMATION Use lower doses in elderly patients The majority of a dose (75%) is excreted by the kidney, mainly as metabolites Tags: post-by-auto-php Continue Reading Previous Previous post: sodium valproate.txt Related News tamsulosin.txt sorafenib.txt