ursodeoxycholic acid.txt

CLINICAL USE

Dissolution of gallstones Primary biliary cirrhosis

DOSE IN NORMAL RENAL FUNCTION

Dissolution of gallstones: 8–12 mg/kg/day in 1–2 divided doses Primary biliary cirrhosis: 10–15 mg/kg/day in 2–4 divided doses

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 392.6

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 96–98

%Excreted unchanged in urine &nbsp &nbsp : 0

Volume of distribution (L/kg) &nbsp &nbsp &nbsp : No data

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : No data

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Dose as in normal renal function

HDF/high flux &nbsp : Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Ciclosporin: unpredictably increases the absorption of ciclosporin in some patients

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

Completely metabolised in the liver and excreted via the faecal route

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