PRESENCE OF ANTIBODIES?
AFTER DECTING HLA MATHCING, ONE SHOULD SCREEN THE PRESENCE OF ANTIBODIES.
Complement Dependent Lymphocytotoxicity (CDC):IgG antibodies directed against HLA class I (on both B and T cells) are the most importantPRA stands for Panel Reactive Antibodies. In order to determine whether or not a patient already has any specific HLA antibodiesWhen PRA positive (there is HLA antibodies), it called the patient is sensitized, and need a procedure called desensitization
sensitization
The definition of sensitization is variable. One definition defines it as moderately sensitized when PRA is >20% and highly sensitized when the PRA >80%. This is however variable between centres.