DESCRIPTION
A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium.
CATEGORIES
Vasodilator Agents, Explosive Agents.
CHEMICAL FORMULA
C3H5N3O9
COMPOSITION
Glyceryl Trinitrate 2.5mg
INDICATION
Glyceryl Trinitrate (also known as GTN) helps relieve sudden attacks of angina (chest pain).
PHARMACODYNAMICS
Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.
No Information
VOLUME DISTRIBUTION
3 L/kg
METABOLISM
Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation
ELIMINATION
In urine, in bile
HALF LIFE
3 minutes
TOXICITY
Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
FOOD INTERACTIONS
Avoid alcohol. Dissolve under the tongue. Take on empty stomach: 1 hour before or 2 hours after meals.
SIDE EFFECTS
If you are taking this medicine for the first few times, you may get a headache, your face may feel flushed and your heart rate may go up. This indicates that the medicine is working and is not a cause for worry. The symptoms should pass. You may also feel dizzy and a little faint. Sit down or find some form of support such as a wall. Seek help from family or bystanders if you do not feel well. If this medicine makes you dizzy or drowsy, do not drive or take part in any activity in which you need to be alert. You may feel a temporary tingling sensation in the tongue or in the mouth. This is harmless and is not a cause for worry.