DESCRIPTION
Ciprofloxacin -A broad-spectrum antimicrobial carboxyfluoroquinoline. Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.Benzalkonium chloride, also known as BZK, BKC, BAC, alkyldimethylbenzylammonium chloride and ADBAC, is a class of cationic surfactants. They are organic salts, called quaternary ammonium compounds. It has three main
CATEGORIES
of use: as a biocide, a cationic surfactant, and phase transfer agent.[2] ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, where the alkyl group has various even-numbered alkyl chain lengths.
CATEGORIES
Ciprofloxacin -Anti-Infective Agents,Quinolones.
CHEMICAL FORMULA
Ciprofloxacin -C17H18FN3O3,
COMPOSITION
Ciprofloxacin 0.3 % w/v + Betamethasone sodium Phosphate 0.01 % w/v +Benzalkonium Chloride solution 0.02% v/v
INDICATION
Ciprofloxacin – For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
PHARMACODYNAMICS
Ciprofloxacin -Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The
MECHANISM
of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
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ABSORPTION
Ciprofloxacin -Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
METABOLISM
Ciprofloxacin -Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.
ELIMINATION
Ciprofloxacin -Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.
HALF LIFE
Ciprofloxacin -4 hours,
TOXICITY
Ciprofloxacin -The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
FOOD INTERACTIONS
avoid alcohol
SIDE EFFECTS
Ciprofloxacin -Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Yogurt or probiotics may help. You may get these products at health food stores or in some pharmacies. Tendons may rarely get irritated and tear. Unsafe allergic effects may rarely happen.