DESCRIPTION
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
CATEGORIES
Anti-Bacterial Agents,Cephalosporins.
CHEMICAL FORMULA
C15H17N5O6S2
COMPOSITION
Cefpodoxime Proxetil 50 mg w/v
INDICATION
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
PHARMACODYNAMICS
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.
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ABSORPTION
Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.
ELIMINATION
Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.
HALF LIFE
2.09 to 2.84 hours
SIDE EFFECTS
What is Cefpodoxime for: It is used to treat bacterial infections. How does Cefpodoxime work: It works to harm the bacteria and fight the infection. How should Cefpodoxime be used: Take Cefpodoxime exactly as directed by your doctor. Do not take more or less than instructed by your doctor. Take Cefpodoxime at regular intervals as instructed. Do not skip any doses. Continue to take it even when you feel better. You must complete the entire course of antibiotic. If you dont, the infection will not clear completely. Take Cefpodoxime with food to improve the absorption. If you have been given tablets, swallow them whole. If you have been given an oral suspension, shake the bottle well before you take it to ensure that the liquid is evenly mixed. Use the measuring spoon or cup provided to measure your dose. Common side effects of Cefpodoxime : Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Yogurt or probiotics may help. You may get these products at health food stores or in some pharmacies. – For women, vaginal yeast infection. Report itching or discharge.