DESCRIPTION
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
CATEGORIES
Laxatives, Purgatives .
CHEMICAL FORMULA
C22H19NO4
COMPOSITION
Bisacodyl 5 mg
INDICATION
Indicated for cleansing of the colon as a preparation for colonoscopy in adults.
PHARMACODYNAMICS
Bisacodyl is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis.
MECHANISM
Induces diarrhea which cleanses the colon.
ABSORPTION
15%
METABOLISM
Hepatic (CYP450-mediated).
ELIMINATION
primarily in the feces, systemically absorbed drug is excreted in the urine
HALF LIFE
16 hours
FOOD INTERACTIONS
avoid alcohol
SIDE EFFECTS
Mild cramps, nausea, diarrhea, abdominal discomfort, stomach and intestinal irritation, faintness, irritation or burning in the rectum (from suppositories and enemas).