DESCRIPTION
Aceclofenac-Aceclofenac is used to relieve pain and inflammation of joints and vertebrae in conditions such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.Thiocolchicoside-Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.
CATEGORIES
Aceclofenac-Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Non-Opioid Analgesics & Antipyretics.Thiocolchicoside-Muscle Relaxants.
CHEMICAL FORMULA
Aceclofenac-C16H13Cl2NO4.Thiocolchicoside-C27H33NO10S.
COMPOSITION
Aceclofenac 100mg + Thiocolchicoside 4mg
INDICATION
Aceclofenac-Aceclofenac works by blocking the effect of chemicals called cyclooxygenase enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Prostaglandins are produced at sites of injury or damage, and cause pain and swelling. By blocking the effect of cyclooxygenase enzymes, production of prostaglandins are reduced, thus, pain and swelling are eased. Thiocolchicoside-Thiocolchicoside is a muscle relaxant which has been claimed to possess GABA-mimetic and glycinergic actions.
PHARMACODYNAMICS
Aceclofenac-Aceclofenac may increase concentrations of lithium, digoxin and methotrexate in the blood, increase the activity of anticoagulants (warfarin), reduce the activity of diuretics (furosemide) and anti-hypertensives, cause increased toxicity in kidney (cyclosporine). Interaction with quinolone antibiotics (ciprofloxacin, levofloxacin), anti-diabetic drugs, pain killers (aspirin, ibuprofen), or corticosteroids can cause adverse effects. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
No Information
SIDE EFFECTS
Aceclofenac-The most common side effects are gastrointestinal in nature including ulcers in the mouth, stomach and small intestine, urge to vomit, vomiting, diarrhea, constipation, excessive passage of wing or gas, indigestion, abdominal pain, blood in stools. Other common side effects are swelling of part or whole of the body, increased blood pressure, heart failure, and severe allergic reactions.Thiocolchicoside-Photosensitivity reactions.