A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms.
CATEGORIES
Gout Suppressants,Enzyme Inhibitors,Antimetabolites,Free Radical Scavengers .
CHEMICAL FORMULA
C5H4N4O
COMPOSITION
Allopurinol 100 MG
INDICATION
For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.
PHARMACODYNAMICS
Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.
No Information
ABSORPTION
Approximately 80-90% absorbed from the gastrointestinal tract.
METABOLISM
Hepatic
ELIMINATION
Approximately 20% of the ingested allopurinol is excreted in the feces.
HALF LIFE
1-3 hours
TOXICITY
LD50=214 mg/kg (in mice)
FOOD INTERACTIONS
avoid alcohol
SIDE EFFECTS
Skin irritation. Upset stomach or throwing up.