Composition
Each film-coated tablet contains: Levofloxacin 500 mg.
Indications
- Acute sinusitis.
- Acute bacterial exacerbations of chronic bronchitis and community-acquired pneumonia.
- Complicated urinary tract infections.
- Skin and soft tissue infections such as abcesses, skin ulcers, cellulitis, and impetigo.
Contraindications
Contraindicated for patients with known hypersensitivity to its ingredients or to other quinolones.
Side Effects
Sometimes: nausea, vomiting, diarrhea, sleep disturbances, headache, dizziness,
tiredness, and pruritus.
Rarely: hypotension, arthralgia, tremor, anxiety, tachycardia, and photosensitivity have been observed which subsided with in few days of withdrawal.
Precautions
Known or suspected CNS disorders or epilepsy, as well as G6PD deficiency.
Elderly patients with decreased renal function and/or patients with low body weight (< 50 kg) may need dosage adjustment. In patients with renal impairment (creatinine clearance less than 40 ml/min), dosage
may need to be adjusted.
Since levofloxacin may cause dizziness, caution is required whilst driving vehicles and operating hazardous machinery.
During therapy, avoid the exposure to excessive sunlight.
Children: Safety and effectiveness in children and adolescent below 18 years of age have not been established.
Pregnancy and Lactation
Levofloxacin is better to be avoided unless the potential benefits outweigh the possible risks.
Drug Interactions
Concomitant administration of sucralfate, antacids containing aluminium hydroxide and/or magnesium hydroxide, vitamins, or minerals containing iron reduces the absorption of oral levofloxacin.
No clinically relevant changes in plasma theophylline, warfarin, cimetidine, digoxin, and cyclosporine concentrations were seen during concomitant administration of levofloxacin; therefore it can be adminisred with these agents.
Dosage and Administration
Jenoquine can be administered without regard to meals.
Acute sinusitis: 500 mg for 10-14 days.
Community-acquired pneumonia: 500 mg once or twice daily for 7-14 days.
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg daily for 7-10 days.
Skin and soft tissues infections: 250 mg daily or 500 mg once or twice daily for 7-14 days.
Packaging
t: 5, 10.