Mode of action
Irreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulated
and basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassium
ATPase.
Indications
Marketed: Peptic ulcer disease (PUD); Gastro-oesophageal reflux disease (GORD); H. pylori eradication, as part of
effective eradication regimen, Dyspepsia.
Accepted: Zollinger–Ellison syndrome; Scleroderma oesophagus; In selected patients for stress ulcer prophylaxis;
Acute upper GI bleeding; prevention of acid aspiration.
Specific considerations
Same as esomeprazole
Adverse effects
PPIs are generally well tolerated.
Common: headache, nausea, diarrhoea, abdominal pain, fatigue, dizziness
Infrequent: pharyngitis, rhinitis, cough, rash, itch, flatulence, constipation.
Rare: agranulocytosis, gynaecomastia, myalgia, interstitial nephritis, raised liver enzymes, hepatitis, jaundice,
thrombocytopenia, leucopenia, Stevens–Johnson syndrome, toxic epidermal necrolysis..
Dosage
PUD: Initially, 30 mg once daily for 4–8 weeks. Maintenance, 15–30 mg once daily.
GORD: Adult, initially, 30 mg once or twice daily. Maintenance, reduce to minimum required.
Child >1 year
<30 kg, 15 mg once daily for 8–12 weeks (maximum 30 mg twice daily).
30 kg, 30 mg once daily for 8–12 weeks (maximum 30 mg twice daily).
Dyspepsia: Initially, 15–30 mg daily for 4–8 weeks.
Zollinger–Ellison syndrome: Adjust dose according to gastric acid output. Initially, 60 mg once daily. Maintenance,
30–180 mg daily (give doses >120 mg daily as 2 divided doses).
H. pylori eradication: 30 mg twice daily for 1 week, with 2 antibiotics.
Severe hepatic impairment: Maximum recommended dose 30 mg daily.
Patient counselling
Swallow capsule whole; do not crush or chew. Alternatively, the capsule may be opened and the contents dispersed
in apple, orange or tomato juice, yoghurt or apple sauce; take immediately.
Add the granules to 30 mL of water, stir well and drink immediately.
Tell your doctor if you develop symptoms such as black stools or coffee-coloured vomit.
Products
LANSOPRAZOLE CAPS/TABS 15 MG (LANSAZOL®, LANSOMID®, LANZOTEC®, LANZOPRAL®,
LANZOR®, LAZAL®, PEPTAZOLE®, TAKEPRON®, ULTRAZOLE®)
LANSOPRAZOLE CAPS/TABS 30 MG (LANSAZOL®, LANSOMID®, LANZOTEC®, LANZOPRAL®,
LANZOR®, LAZAL®, PEPTAZOLE®, TAKEPRON®, ULTRAZOLE®)