2022

LANSOPRAZOLE

Mode of actionIrreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulatedand basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassiumATPase.IndicationsMarketed:…

ESOMEPRAZOLE

Mode of actionIrreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulatedand basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassiumATPase.IndicationsGastro-oesophageal…

RANITIDINE

Mode of actioncompetitively block H2 receptors on parietal cells, reducing gastric acid secretion.IndicationsMarketed: Peptic ulcer disease (PUD); Gastro-oesophageal reflux disease (GORD); Dyspepsia.Accepted: Stress ulcer prophylaxis.ContraindicationsAcute porphyria.Specific considerationsPhenylketonuria: effervescent tablets contain…

FAMOTIDINE

FAMOTIDINE IndicationsPeptic ulcer disease (PUD); Gastro-oesophageal reflux disease (GORD); Dyspepsia.Specific considerationsPhenylketonuria: effervescent tablets contain aspartame.Renal impairment: Although renally cleared, dosage reduction is rarely required in renal impairment.Surgery: Continue treatment throughout…