Acnil
Generic: ACNIL CLINDAMYCIN HYDROCHLORIDE AND METRONIDAZOLE LINIMENT
Basic Information
Manufacturer
Jiangsu Chenpai Bond Pharmaceutical Co.,Ltd.
Product Type
HUMAN OTC DRUG
Route of Administration
TOPICAL
FDA Set ID
178bf5ec-2282-cd65-e063-6294a90ae64b
Purpose
DESCRIPTION Acolorless or slightly yellow clear liquid; with an odour of alcohol.
PHARMACOLOGY AND TOXICOLOGY Clindamycin Hydrochloride is a bacteriostatic antibiotic, which is 4 to 8 times more potent than Lincomycin.
It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis.
It also has good antibacterial activity to anaerobic gram-negative bacterium.
Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it.
It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis.
Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration.
Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent.
Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing.
As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid.
INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin.
It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose.
Drug Interactions: There is antagonism between ACNIL and erythromycin, so the combination of ACNIL and erythromycin is forbidden.
PHARMACOLOGY AND TOXICOLOGY Clindamycin Hydrochloride is a bacteriostatic antibiotic, which is 4 to 8 times more potent than Lincomycin.
It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis.
It also has good antibacterial activity to anaerobic gram-negative bacterium.
Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it.
It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis.
Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration.
Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent.
Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing.
As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid.
INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin.
It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose.
Drug Interactions: There is antagonism between ACNIL and erythromycin, so the combination of ACNIL and erythromycin is forbidden.
Indications & Usage
PHARMACOLOGY AND TOXICOLOGY Clindamycin Hydrochloride is a bacteriostatic antibiotic, which is 4 to 8 times more potent than Lincomycin.
It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis.
It also has good antibacterial activity to anaerobic gram-negative bacterium.
Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it.
It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis.
Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration.
Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent.
Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing.
As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid.
INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin.
It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose.
It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis.
It also has good antibacterial activity to anaerobic gram-negative bacterium.
Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it.
It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis.
Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration.
Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent.
Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing.
As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid.
INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin.
It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose.
Warnings
ADVERSE REACTIONS: A few instance of local irritation or burning sensation may be observed.
occasionally during the treatment.
Allergic reaction can be observed rarely.