fluconazole  - Removal Estimates

💊 fluconazole 

fluconazole  Dialyzability By Different Modalities

MW: 306.277
Protein Binding: 11–12%%
Vd: 0.65 L/kg

📊 Removal Estimates

Estimates based on drug properties and standard treatment parameters.

🩸

Hemodialysis

230.7 mL/min
Highly Dialyzable
Significant removal expected. Half-life: 30 hours (range 20–50 hours). Consider post-dialysis supplementation.
Data Used:
✅ protein_binding, molar_mass, mw_factor, vd, vd_factor, half_life
Free fraction: 0.89 Mw factor: 1 Vd factor: 0.8 Hl factor: 1.2 Half life: 30 hours (range 20–50 hours) Half life category: Very Long (24-72h)
🫀

Peritoneal Dialysis

4.0 mL/min
Low PD Clearance
Minimal removal expected. No supplementation needed. Half-life: 30 hours (range 20–50 hours).
Data Used:
✅ protein_binding, molar_mass, half_life
Free fraction: 0.89 Half life: 30 hours (range 20–50 hours) Half life category: Very Long (24-72h)
🔄

Plasmapheresis (TPE)

Low Risk
This drug is unlikely to be significantly removed by TPE.
Data Used:
✅ protein_binding, vd, half_life
Half life: 30 hours (range 20–50 hours) Half life category: Very Long (24-72h)
🧪

Hemoadsorption

Moderate Effectiveness
Some removal possible. May be useful in overdose.
Data Used:
✅ vd, half_life
Half life: 30 hours (range 20–50 hours) Half life category: Very Long (24-72h)

📋 Summary of Estimates

Modality Clearance/Value Half-Life Classification Data Quality
Hemodialysis 230.7 mL/min 30 hours (range 20–50 hours) Highly Dialyzable Complete Data
Peritoneal Dialysis 4.0 mL/min 30 hours (range 20–50 hours) Low PD Clearance Complete Data
Plasmapheresis (TPE) Low Risk 30 hours (range 20–50 hours) N/A Complete Data
Hemoadsorption Moderate Effectiveness 30 hours (range 20–50 hours) N/A Complete Data

📌 Important Notes

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