methotrexate  - Removal Estimates

💊 methotrexate 

methotrexate  Dialyzability By Different Modalities

MW: 454.447
Protein Binding: 35–50% (parent drug), 91–93% (7-hydroxymethotrexate)%
Vd: 0.4 L/kg

📊 Removal Estimates

Estimates based on drug properties and standard treatment parameters.

🩸

Hemodialysis

175.5 mL/min
Highly Dialyzable
Significant removal expected. Half-life: 10 hours (lower doses). Consider post-dialysis supplementation.
Data Used:
✅ protein_binding, molar_mass, mw_factor, vd, vd_factor, half_life
Free fraction: 0.65 Mw factor: 1 Vd factor: 1 Hl factor: 1 Half life: 10 hours (lower doses) Half life category: Intermediate (4-12h)
🫀

Peritoneal Dialysis

2.8 mL/min
Low PD Clearance
Minimal removal expected. No supplementation needed. Half-life: 10 hours (lower doses).
Data Used:
✅ protein_binding, molar_mass, half_life
Free fraction: 0.65 Half life: 10 hours (lower doses) Half life category: Intermediate (4-12h)
🔄

Plasmapheresis (TPE)

Moderate Risk
This drug may be removed by TPE. Consider monitoring levels.
Data Used:
✅ protein_binding, vd, half_life
Half life: 10 hours (lower doses) Half life category: Intermediate (4-12h)
🧪

Hemoadsorption

Moderate Effectiveness
Some removal possible. May be useful in overdose.
Data Used:
✅ vd, half_life
Half life: 10 hours (lower doses) Half life category: Intermediate (4-12h)

📋 Summary of Estimates

Modality Clearance/Value Half-Life Classification Data Quality
Hemodialysis 175.5 mL/min 10 hours (lower doses) Highly Dialyzable Complete Data
Peritoneal Dialysis 2.8 mL/min 10 hours (lower doses) Low PD Clearance Complete Data
Plasmapheresis (TPE) Moderate Risk 10 hours (lower doses) N/A Complete Data
Hemoadsorption Moderate Effectiveness 10 hours (lower doses) N/A Complete Data

📌 Important Notes

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