Dyrenium
Generic: TRIAMTERENE
Basic Information
Manufacturer
Advanz Pharma (US) Corp.
Product Type
HUMAN PRESCRIPTION DRUG
Route of Administration
ORAL
FDA Set ID
ebb177c0-d45d-4443-a85a-e76bd9931a42
Indications & Usage
INDICATIONS AND USAGE Dyrenium (triamterene) is indicated in the treatment of edema associated with congestive heart failure, cirrhosis of the liver and the nephrotic syndrome; steroid-induced edema, idiopathic edema and edema due to secondary hyperaldosteronism.
Dyrenium may be used alone or with other diuretics, either for its added diuretic effect or its potassium-sparing potential.
It also promotes increased diuresis when patients prove resistant or only partially responsive to thiazides or other diuretics because of secondary hyperaldosteronism.
Usage in Pregnancy .
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.
Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy.
Diuretics are indicated in pregnancy (however, see PRECAUTIONS below) when edema is due to pathologic causes, just as they are in the absence of pregnancy.
Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary.
There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women.
If this edema produces discomfort, increased recumbency will often provide relief.
In rare instances, this edema may cause extreme discomfort which is not relieved by rest.
In these cases, a short course of diuretics may provide relief and may be appropriate.
Dyrenium may be used alone or with other diuretics, either for its added diuretic effect or its potassium-sparing potential.
It also promotes increased diuresis when patients prove resistant or only partially responsive to thiazides or other diuretics because of secondary hyperaldosteronism.
Usage in Pregnancy .
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.
Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy.
Diuretics are indicated in pregnancy (however, see PRECAUTIONS below) when edema is due to pathologic causes, just as they are in the absence of pregnancy.
Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary.
There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women.
If this edema produces discomfort, increased recumbency will often provide relief.
In rare instances, this edema may cause extreme discomfort which is not relieved by rest.
In these cases, a short course of diuretics may provide relief and may be appropriate.
Adverse Reactions
ADVERSE REACTIONS Adverse effects are listed in decreasing order of frequency; however, the most serious adverse effects are listed first, regardless of frequency.
All adverse effects occur rarely (that is, 1 in 1000, or less).
Hypersensitivity: anaphylaxis, rash, photosensitivity.
Metabolic: hyperkalemia, hypokalemia.
Renal: azotemia, elevated BUN and creatinine, renal stones, acute interstitial nephritis (rare), acute renal failure (one case of irreversible renal failure has been reported).
Gastrointestinal: jaundice and/or liver enzyme abnormalities, nausea and vomiting, diarrhea.
Hematologic: thrombocytopenia, megaloblastic anemia.
Central Nervous System: weakness, fatigue, dizziness, headache, dry mouth.
To report SUSPECTED ADVERSE REACTIONS, contact Advanz Pharma (US) Corp.
at 1-877-370-1142 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
All adverse effects occur rarely (that is, 1 in 1000, or less).
Hypersensitivity: anaphylaxis, rash, photosensitivity.
Metabolic: hyperkalemia, hypokalemia.
Renal: azotemia, elevated BUN and creatinine, renal stones, acute interstitial nephritis (rare), acute renal failure (one case of irreversible renal failure has been reported).
Gastrointestinal: jaundice and/or liver enzyme abnormalities, nausea and vomiting, diarrhea.
Hematologic: thrombocytopenia, megaloblastic anemia.
Central Nervous System: weakness, fatigue, dizziness, headache, dry mouth.
To report SUSPECTED ADVERSE REACTIONS, contact Advanz Pharma (US) Corp.
at 1-877-370-1142 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.