INDICATIONS AND USAGE Ribavirin for Inhalation Solution, USP is indicated for the treatment of hospitalized infants and young children with severe lower respiratory tract infections due to RSV.

Treatment early in the course of severe lower respiratory tract infection may be necessary to achieve efficacy.

Only severe RSV lower respiratory tract infection should be treated with Ribavirin for Inhalation Solution, USP.

The vast majority of infants and children with RSV infection have disease that is mild, self-limited, and does not require hospitalization or antiviral treatment.

Many children with mild lower respiratory tract involvement will require shorter hospitalization than would be required for a full course of Ribavirin for Inhalation Solution, USP aerosol (3 to 7 days) and should not be treated with the drug.

Thus the decision to treat with Ribavirin for Inhalation Solution, USP should be based on the severity of the RSV infection.

The presence of an underlying condition such as prematurity, immunosuppression or cardiopulmonary disease may increase the severity of clinical manifestations and complications of RSV infection.

Use of aerosolized Ribavirin for Inhalation Solution, USP in patients requiring mechanical ventilator assistance should be undertaken only by physicians and support staff familiar with this mode of administration and the specific ventilator being used (see WARNINGS and DOSAGE AND ADMINISTRATION ).

Diagnosis RSV infection should be documented by a rapid diagnostic method such as demonstration of viral antigen in respiratory tract secretions by immunofluorescence 3,4 or ELISA 5 before or during the first 24 hours of treatment.

Treatment may be initiated while awaiting rapid diagnostic test results.

However, treatment should not be continued without documentation of RSV infection.

Non-culture antigen detection techniques may have false positive or false negative results.

Assessment of the clinical situation, the time of year and other parameters may warrant reevaluation of the laboratory diagnosis.

Description of Studies Non-Mechanically Ventilated Infants In two placebo-controlled trials in infants hospitalized with RSV lower respiratory tract infection, aerosolized Ribavirin for Inhalation Solution, USP treatment had a therapeutic effect, as judged by the reduction in severity of clinical manifestations of disease by treatment day 3.

3,4 Treatment was most effective when instituted within the first 3 days of clinical illness.

Virus titers in respiratory secretions were also significantly reduced with Ribavirin for Inhalation Solution, USP in one of these original studies.

4 Additional controlled studies conducted since these initial trials of aerosolized Ribavirin for Inhalation Solution, USP in the treatment of RSV infection have supported these data.

Mechanically Ventilated Infants A randomized, double-blind, placebo-controlled evaluation of aerosolized Ribavirin for Inhalation Solution, USP at the recommended dose was conducted in 28 infants requiring mechanical ventilation for respiratory failure caused by documented RSV infection.

6 Mean age was 1.4 months (SD, 1.7 months).

Seven patients had underlying diseases predisposing them to severe infection and 21 were previously normal.

Aerosolized Ribavirin for Inhalation Solution, USP treatment significantly decreased the duration of mechanical ventilation required (4.9 vs.

9.9 days, p=0.01) and duration of required supplemental oxygen (8.7 vs.

13.5 days, p=0.01).

Intensive patient management and monitoring techniques were employed in this study.

These included endotracheal tube suctioning every 1 to 2 hours; recording of proximal airway pressure, ventilatory rate, and F l O 2 every hour; and arterial blood gas monitoring every 2 to 6 hours.

To reduce the risk of Ribavirin for Inhalation Solution, USP precipitation and ventilator malfunction, heated wire tubing, two bacterial filters connected in series in the expiratory limb of the ventilator (with filter changes every 4 hours), and water column pressure release valves to monitor internal ventilator pressures were used in connecting ventilator circuits to the SPAG ® -2.

Employing these techniques, no technical difficulties with Ribavirin for Inhalation Solution, USP administration were encountered during the study.

Adverse events consisted of bacterial pneumonia in one case, staphylococcus bacteremia in one case and two cases of post-extubation stridor.

None were felt to be related to Ribavirin for Inhalation Solution, USP administration.

WARNINGS SUDDEN DETERIORATION OF RESPIRATORY FUNCTION HAS BEEN ASSOCIATED WITH INITIATION OF AEROSOLIZED RIBAVIRIN FOR INHALATION SOLUTION, USP USE IN INFANTS.

Respiratory function should be carefully monitored during treatment.

If initiation of aerosolized Ribavirin for Inhalation Solution, USP treatment appears to produce sudden deterioration of respiratory function, treatment should be stopped and reinstituted only with extreme caution, continuous monitoring, and consideration of concomitant administration of bronchodilators.

Use with Mechanical Ventilators USE OF AEROSOLIZED RIBAVIRIN FOR INHALATION SOLUTION, USP IN PATIENTS REQUIRING MECHANICAL VENTILATOR ASSISTANCE SHOULD BE UNDERTAKEN ONLY BY PHYSICIANS AND SUPPORT STAFF FAMILIAR WITH THIS MODE OF ADMINISTRATION AND THE SPECIFIC VENTILATOR BEING USED.

Strict attention must be paid to procedures that have been shown to minimize the accumulation of drug precipitate, which can result in mechanical ventilator dysfunction and associated increased pulmonary pressures.

These procedures include the use of bacteria filters in series in the expiratory limb of the ventilator circuit with frequent changes (every 4 hours), water column pressure release valves to indicate elevated ventilator pressures, frequent monitoring of these devices and verification that ribavirin crystals have not accumulated within the ventilator circuitry, and frequent suctioning and monitoring of the patient (see Description of Studies ).

Those administering aerosolized Ribavirin for Inhalation Solution, USP in conjunction with mechanical ventilator use should be thoroughly familiar with detailed descriptions of these procedures as outlined in the SPAG-2 Instructions for Use.

ADVERSE REACTIONS The description of adverse reactions is based on events from clinical studies (approximately 200 patients) conducted prior to 1986, and the controlled trial of aerosolized Ribavirin for Inhalation Solution, USP conducted in 1989-1990.

Additional data from spontaneous post-marketing reports of adverse events in individual patients have been available since 1986.

Deaths Deaths during or shortly after treatment with aerosolized Ribavirin for Inhalation Solution, USP have been reported in 20 cases of patients treated with Ribavirin for Inhalation Solution, USP (12 of these patients were being treated for RSV infections).

Several cases have been characterized as "possibly related" to Ribavirin for Inhalation Solution, USP by the treating physician; these were in infants who experienced worsening respiratory status related to bronchospasm while being treated with the drug.

Several other cases have been attributed to mechanical ventilator malfunction in which Ribavirin for Inhalation Solution, USP precipitation within the ventilator apparatus led to excessively high pulmonary pressures and diminished oxygenation.

In these cases the monitoring procedures described in the current package insert were not employed (see Description of Studies , WARNINGS , and DOSAGE AND ADMINISTRATION ).

Pulmonary and Cardiovascular Pulmonary function significantly deteriorated during aerosolized Ribavirin for Inhalation Solution, USP treatment in six of six adults with chronic obstructive lung disease and in four of six asthmatic adults.

Dyspnea and chest soreness were also reported in the latter group.

Minor abnormalities in pulmonary function were also seen in healthy adult volunteers.

In the original study population of approximately 200 infants who received aerosolized Ribavirin for Inhalation Solution, USP, several serious adverse events occurred in severely ill infants with lifethreatening underlying diseases, many of whom required assisted ventilation.

The role of Ribavirin for Inhalation Solution, USP in these events is indeterminate.

Since the drug's approval in 1986, additional reports of similar serious, though non-fatal, events have been filed infrequently.

Events associated with aerosolized Ribavirin for Inhalation Solution, USP use have included the following: Pulmonary Worsening of respiratory status, bronchospasm, pulmonary edema, hypoventilation, cyanosis, dyspnea, bacterial pneumonia, pneumothorax, apnea, atelectasis and ventilator dependence.

Cardiovascular Cardiac arrest, hypotension, bradycardia and digitalis toxicity.

Bigeminy, bradycardia and tachycardia have been described in patients with underlying congenital heart disease.

Some subjects requiring assisted ventilation experienced serious difficulties, due to inadequate ventilation and gas exchange.

Precipitation of drug within the ventilatory apparatus, including the endotracheal tube, has resulted in increased positive end expiratory pressure and increased positive inspiratory pressure.

Accumulation of fluid in tubing ("rain out") has also been noted.

Measures to avoid these complications should be followed carefully (see DOSAGE AND ADMINISTRATION ).

Hematologic Although anemia was not reported with use of aerosolized Ribavirin for Inhalation Solution, USP in controlled clinical trials, most infants treated with the aerosol have not been evaluated 1 to 2 weeks post-treatment when anemia is likely to occur.

Anemia has been shown to occur frequently with experimental oral and intravenous Ribavirin for Inhalation Solution, USP in humans.

Also, cases of anemia (type unspecified), reticulocytosis and hemolytic anemia associated with aerosolized Ribavirin for Inhalation Solution, USP use have been reported through post-marketing reporting systems.

All have been reversible with discontinuation of the drug.

Other Rash and conjunctivitis have been associated with the use of aerosolized Ribavirin for Inhalation Solution, USP.

These usually resolve within hours of discontinuing therapy.

Seizures and asthenia associated with experimental intravenous Ribavirin for Inhalation Solution, USP therapy have also been reported.

Adverse Events in Health Care Workers Studies of environmental exposure to aerosolized Ribavirin for Inhalation Solution, USP in health care workers administering care to patients receiving the drug have not detected adverse signs or symptoms related to exposure.

However, 152 health care workers have reported experiencing adverse events through post-marketing surveillance.

Nearly all were in individuals providing direct care to infants receiving aerosolized Ribavirin for Inhalation Solution, USP.

Of 358 events from these 152 individual health care worker reports, the most common signs and symptoms were headache (51% of reports), conjunctivitis (32%), and rhinitis, nausea, rash, dizziness, pharyngitis, or lacrimation (10-20% each).

Several cases of bronchospasm and/or chest pain were also reported, usually in individuals with known underlying reactive airway disease.

Several case reports of damage to contact lenses after prolonged close exposure to aerosolized Ribavirin for Inhalation Solution, USP have also been reported.

Most signs and symptoms reported as having occurred in exposed health care workers resolved within minutes to hours of discontinuing close exposure to aerosolized Ribavirin for Inhalation Solution, USP (also see Information for Health Care Personnel ).

The symptoms of RSV in adults can include headache, conjunctivitis, sore throat and/or cough, fever, hoarseness, nasal congestion and wheezing, although RSV infections in adults are typically mild and transient.

Such infections represent a potential hazard to uninfected hospital patients.

It is unknown whether certain symptoms cited in reports from health care workers were due to exposure to the drug or infection with RSV.

Hospitals should implement appropriate infection control procedures.

To report SUSPECTED ADVERSE REACTIONS, contact Cameron Pharmaceuticals at 1-888-767-7913 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.