INDICATIONS AND USAGE Collagenase Santyl ◊ Ointment is indicated for debriding chronic dermal ulcers 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and severely burned areas.

3, 4, 5, 7, 16, 19, 20, 21

ADVERSE REACTIONS No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed.

However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than one year with a combination of collagenase and cortisone has been reported.