Antipsychotic for schizophrenia and other psychoses
DOSE IN NORMAL RENAL FUNCTION
Schizophrenia and paranoid psychoses: Oral: 20–30 mg daily in divided doses; maximum 150 mg daily Maintenance:
20 to 50     : mg daily Deep IM: 200–500 mg every 1–4 weeks Maximum: 600 mg weekly Acute psychoses: (Clopixol Acuphase) Deep IM: 50–150 mg, repeated if required after 2–3 days Maximum 400 mg per course
PHARMACOKINETICS
Molecular weight                           : 401 (443 as acetate), (473.9 as hydrochloride), (555.2 as decanoate)
Antimalarials: avoid concomitant use with artemether/lumefantrine
Antipsychotics: avoid concomitant use of clozapine with depot preparations in case of neutropenia
Antivirals: concentration possibly increased with ritonavir Anxiolytics and hypnotics: increased sedative effects
Sibutramine: increased risk of CNS toxicity – avoid concomitant use Avoid concomitant use with drugs that prolong the QT interval
ADMINISTRATION
Reconstition
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Route
Oral, IM
Rate of Administration
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Comments
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OTHER INFORMATION
May cause hypotension and excessive sedation Increased CNS sensitivity in renally impaired patients – start with small doses as can accumulate Peak levels occur 3–6 hours after oral administration .the liver. It can be used in renal failure at normal doses with caution.