Zolpidem tartrate.txt CLINICAL USE Insomnia (short-term treatment) DOSE IN NORMAL RENAL FUNCTION 5–10 mg at night PHARMACOKINETICS Molecular weight                           : 764.9 %Protein binding                           : 92.5 %Excreted unchanged in urine     : Negligible (56% as active metabolites) Volume of distribution (L/kg)       : 0.34–0.54 (depends on age) half-life – normal/ESRD (hrs)      : Average: 2.4/ Increased DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                : Not dialysed. Dose as in normal renal function HD                     : Not dialysed. Dose as in normal renal function HDF/high flux   : Unknown dialysability. Dose as in normal renal function CAV/VVHD      : Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antibacterials: metabolism accelerated by rifampicin Antipsychotics: enhanced sedative effects Antivirals: concentration increased by ritonavir (risk of extreme sedation and respiratory depression) – avoid concomitant use ADMINISTRATION Reconstition – Route Oral Rate of Administration – Comments – OTHER INFORMATION First pass metabolism by liver is 35% Clearance is reduced in renal impairment . Tags: post-by-auto-php Continue Reading Previous Previous post: VOLVULUS.txtNext Next post: Zuclopenthixol.txt Related News sotalol hydrochloride.txt tazocin.txt