20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                : Unknown dialysability. Dose as in normal renal function
HD                     : Unknown dialysability. Dose as in normal renal function
HDF/high flux   : Unknown dialysability. Dose as in normal renal function
CAV/VVHD      : Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antibacterials: quinolones possibly inhibit metabolism – reduce dose of zolmitriptan
Antidepressants: risk of CNS toxicity with MAOIs and moclobemide – reduce dose of zolmitriptan to max 7.5 mg; SSRIs inhibit metabolism of zolmitriptan; possibly increased serotonergic effects with duloxetine; increased serotonergic effects with St John’s wort – avoid concomitant use Cimetidine: inhibits metabolism of zolmitriptan; maximum dose is 5 mg
Ergot alkaloids: increased risk of vasospasm Linezolid: risk of CNS toxicity – reduce dose of zolmitriptan