{"id":4713,"date":"2025-03-31T18:12:17","date_gmt":"2025-03-31T18:12:17","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tramadol-hydrochloride-txt\/"},"modified":"2025-03-31T18:12:17","modified_gmt":"2025-03-31T18:12:17","slug":"tramadol-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tramadol-hydrochloride-txt\/","title":{"rendered":"tramadol hydrochloride.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Analgesic

DOSE IN NORMAL RENAL FUNCTION <\/H3> Oral: 50\u2013100 mg up to 4 hourly; maximum 400 mg daily IM\/IV: 50\u2013100 mg every 4\u20136 hours; total daily dose 600 mg

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 299.8 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 20 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 163\u2013243 litres <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 6\/11

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 50\u2013100 mg every 8 hours initially and titrate dose as tolerated
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50 mg every 8 hours initially and titrate dose as tolerated

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/ min
  • HDF\/high flux &nbsp : Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/ min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Dialysed. Dose as in GFR=10\u2013 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • Anticoagulants: enhances effect of coumarins\n
  • Antidepressants: possibly increased serotonergic effects with duloxetine; possible CNS excitation or depression with MAOIs and moclobemide \u2013 avoid concomitant use with MAOIs; increased risk of CNS toxicity with SSRIs or tricyclics\n
  • Anti-epileptics: effect reduced by carbamazepine\n
  • Antivirals: concentration possibly increased by ritonavir\n
  • Atomoxetine: increased risk of convulsions\n
  • Dopaminergics: use selegiline with caution Sodium oxybate: enhanced effect of sodium oxybate \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> IV, IM, oral

    Rate of Administration <\/H4> Slow bolus or continuous

    IV infusion <\/H4>\/PCA

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> Tramadol is a centrally acting opioid agonist which also acts on inhibitory pain pathways .
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Analgesic DOSE IN NORMAL RENAL FUNCTION Oral: 50\u2013100<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4713","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4713"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4713\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}