{"id":4710,"date":"2025-03-31T18:12:17","date_gmt":"2025-03-31T18:12:17","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/terbutaline-sulphate-txt\/"},"modified":"2025-03-31T18:12:17","modified_gmt":"2025-03-31T18:12:17","slug":"terbutaline-sulphate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/terbutaline-sulphate-txt\/","title":{"rendered":"terbutaline sulphate.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Beta2\u2013adrenoceptor agonist: Reversible airways obstruction

DOSE IN NORMAL RENAL FUNCTION <\/H3> Oral: 2.5\u20135 mg 3 times daily SC\/IM\/IV: 250\u2013500 micrograms up to 4 times daily

IV infusion <\/H4>: 90\u2013300 micrograms\/hour Turbohaler: 500 micrograms (1 inhalation) up to 4 times daily Nebulisation: 5\u201310 mg 2\u20134 times daily, or more frequently

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 548.6 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 15\u201325 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 55\u201360 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 0.9\u20131.5 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 16\u201320\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : 50% of normal parenteral dose. Other routes Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 50% of normal parenteral dose. Other routes. Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Avoid parenteral dose. Other routes Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Likely dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Likely dialysability. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp : Likely dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Likely dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs Effect may be diminished by beta-blockers Theophylline: increased risk of hypokalaemia

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> IV, SC, IM, oral, inhaled, nebulised

    Rate of Administration <\/H4> 1.5\u20135 mcg\/minute

    Comments<\/H4> For

    IV infusion <\/H4>, add 1.5\u20132.5 mg to 500 mL glucose 5% or sodium chloride 0.9% (3\u20135 micrograms\/mL)
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Beta2\u2013adrenoceptor agonist: Reversible airways obstruction DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4710","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4710"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4710\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}