{"id":4708,"date":"2025-03-31T18:12:17","date_gmt":"2025-03-31T18:12:17","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tazocin-txt\/"},"modified":"2025-03-31T18:12:17","modified_gmt":"2025-03-31T18:12:17","slug":"tazocin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tazocin-txt\/","title":{"rendered":"tazocin.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>2.25\u20134.5 g every 6\u20138 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Piperacillin: 539.5, Tazobactam: 322.3 (as sodium)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Piperacillin: 20\u201330, Tazobactam: 20\u201330<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Piperacillin: 60\u201380, Tazobactam: 80 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Piperacillin: 0.18\u20130.3, Tazobactam: 0.18\u20130.331<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Piperacillin: 1\/4\u20136, Tazobactam: 1\/7

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 4.5 g every 8\u201312 hours, or 2.25 g every 6 hours
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 4.5 g every 12 hours, or 2.25 g every 8 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/minute<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/minute
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/minute
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201320 mL\/minute, or 2.25 g every 6 hours,1 or 4.5 g every 12 hoursCVVhd\/HDFDialysed: 2.25\u20133.375 g every 6 hours,1 or 4.5 g every 8 hours

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsReduced excretion of methotrexate \u2013 monitor methotrexate levels during concomitant treatmentEnhanced action of vecuronium and similar neuromuscular blocking agents

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Reconstitute each 4.5 g with 20 mL sterile water for injection or sodium chloride 0.9%

    Route <\/H4>IV

    Rate of Administration <\/H4>IV bolus over 3\u20135 minutes

    IV infusion <\/H4> over 20\u201330 minutes

    Comments<\/H4>May be given as an infusion in glucose 5% or sodium chloride 0.9%

    OTHER INFORMATION <\/H4>Sodium content is 2.79 mmol\/g of injectionHas been used intraperitoneally for treatment of PD peritonitis at a concentration of 250 mg\/LPatients with renal impairment are at a greater risk of neuromuscular excitability or convulsions that are associated with overdoseMay cause in vitro inactivation of aminoglycosides6\u201321% is removed by peritoneal dialysis and 30\u201350% by haemodialysis plus an extra 5% as the metabolite
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 2.25\u20134.5<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4708","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4708"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4708\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}