{"id":4707,"date":"2025-03-31T18:12:17","date_gmt":"2025-03-31T18:12:17","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tamsulosin-txt\/"},"modified":"2025-03-31T18:12:17","modified_gmt":"2025-03-31T18:12:17","slug":"tamsulosin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tamsulosin-txt\/","title":{"rendered":"tamsulosin.txt"},"content":{"rendered":"

hydrochloride

CLINICAL USE <\/H3>
\nTreatment of benign prostatic hyperplasia

DOSE IN NORMAL RENAL FUNCTION <\/H3>400 mcg in the morning after breakfast

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :445<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :99<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 9<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.2<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :4\u20135.5 (M\/R: 10\u201315)\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anaesthetics: enhanced hypotensive effect\n
  • Antidepressants: enhanced hypotensive effect with MAOIs\n
  • Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect\n
  • Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect\n
  • Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect\n
  • Moxisylyte: possibly severe postural hypotension\n
  • Vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Swallow whole with 150 mL of water while sitting or standingProtein binding is increased in renal impairment
    \n","protected":false},"excerpt":{"rendered":"

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