{"id":4700,"date":"2025-03-31T18:12:17","date_gmt":"2025-03-31T18:12:17","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/sulfasalazine-txt\/"},"modified":"2025-03-31T18:12:17","modified_gmt":"2025-03-31T18:12:17","slug":"sulfasalazine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/sulfasalazine-txt\/","title":{"rendered":"sulfasalazine.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nUlcerative colitis Crohn\u2019s disease Rheumatoid arthritis

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 1\u20132 g 4 times daily, reduced to 0.5 g 4 times dailyEnema: 3 g at night Suppositories: 0.5\u20131 g twice daily Rheumatoid arthritis: 0.5 g daily, increased to 1.5 g twice daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :398.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :95\u201399<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 10\u201315<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :5.9\u20139.1<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :18\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function. Use with caution
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function. Use with caution
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Start at very low dose and monitor. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Ciclosporin: may reduce ciclosporin levels

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, rectal

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>15% of a dose of sulfasalazine is absorbed in the small intestine and becomes highly bound to plasma proteins. The remainder is split into sulfapyridine and 5-ASA by colonic bacteria. Sulfapyridine is rapidly absorbed from the colon, whereas 5-ASA is poorly absorbed
    Most of a dose of sulfasalazine is excreted in the urine. Unchanged sulfasalazine accounts for 15% of the original dose, sulfapyridine and its metabolites 60%, and 5-ASA and its metabolites 20\u201333%
    Unabsorbed drug is excreted in the faeces In patients with moderate to severe renal impairment, toxicity includes increased risk of crystalluria \u2013 ensure high fluid intake
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Ulcerative colitis Crohn\u2019s disease Rheumatoid arthritis DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4700","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4700"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4700\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}