{"id":4689,"date":"2025-03-31T18:12:16","date_gmt":"2025-03-31T18:12:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/sodium-nitroprusside-txt\/"},"modified":"2025-03-31T18:12:16","modified_gmt":"2025-03-31T18:12:16","slug":"sodium-nitroprusside-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/sodium-nitroprusside-txt\/","title":{"rendered":"sodium nitroprusside.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nHypertensive crisis Heart failure Controlled hypotension in surgery

DOSE IN NORMAL RENAL FUNCTION <\/H3>0.3\u20138 micrograms\/kg\/minute Maintenance of blood pressure: 20\u2013400 mcg\/minuteHeart failure: 10\u2013200 mcg\/minute Controlled blood pressure in surgery: maximum 1.5 mcg\/kg\/minute

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :297.9<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.2<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u201310 minutes\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function. Avoid prolonged use
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Avoid prolonged use

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anaesthetics: enhanced hypotensive effect

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>2\u20133 mL glucose 5%

    Route <\/H4>IV

    Rate of Administration <\/H4>10\u2013400 micrograms\/minute, adjusted according to response

    Comments<\/H4>Dilute 50 mg in 250\u20131000 mL glucose 5% to give a concentration of 50\u2013200 mcg\/mLMinimum volume is 1 mg\/mL via central line. (UK Critical Care Group Minimum Infusion Volumes for fluid restricted critically ill patients, 3rd Edition, 2006)Wrap syringes and lines in foil to protect from light

    OTHER INFORMATION <\/H4>Sodium nitroprusside is rapidly metabolised to cyanogen which is converted to thiocyanateAvoid prolonged use in renal impairment because accumulation of thiocyanate (which is dialysable) may cause seizures or a comaMonitor thiocyanate and cyanide levels Do not stop infusion abruptly \u2013 tail off over 10\u201330 minutessodium nitroprusside.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Hypertensive crisis Heart failure Controlled hypotension in surgery<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4689","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4689"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4689\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}