{"id":4685,"date":"2025-03-31T18:12:16","date_gmt":"2025-03-31T18:12:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/sodium-bicarbonate-txt\/"},"modified":"2025-03-31T18:12:16","modified_gmt":"2025-03-31T18:12:16","slug":"sodium-bicarbonate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/sodium-bicarbonate-txt\/","title":{"rendered":"sodium bicarbonate.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nMetabolic acidosis Alkalinisation of urine Renoprotection against contrast media

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 0.5\u20131.5 g 3 times daily (or more may be required)IV: 8.4%, 60\u2013120 mL per hour; 4.2%, up to 120 mL per hour; 1.26% or 1.4% – see \u2018Other Information\u2019

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :84<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Dependent on the physical state of the patient at the time<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :No data

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsIncreases lithium excretion

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IV, central administration for undiluted infusion

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Caution \u2013 may result in sodium retention and oedemaSodium bicarbonate 1.26% or 1.4% may be given IV to prevent the nephrotoxicity associated with scans or procedures involving radiological contrast media. A typical hydration regimen is 3 ml\/kg\/hour for 1 hour prior to the procedure, followed by 1 mL\/kg\/hour for 6 hours afterwards8.4% \u2261 1 mmol bicarbonate + 1 mmol sodium per mL500 mg sodium bicarbonate tablet \u2261 6 mmol sodium + 6 mmol bicarbonateSodium bicarbonate reduces serum potassium concentrations by inducing a shift of potassium ions into the cellA sugar free raspberry flavoured oral solution of 8.4% sodium bicarbonate is available from Martindalesodium bicarbonate.
    \n","protected":false},"excerpt":{"rendered":"

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