{"id":4680,"date":"2025-03-31T18:12:16","date_gmt":"2025-03-31T18:12:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/sildenafil-txt\/"},"modified":"2025-03-31T18:12:16","modified_gmt":"2025-03-31T18:12:16","slug":"sildenafil-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/sildenafil-txt\/","title":{"rendered":"sildenafil.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nTreatment of erectile dysfunction (ED) To increase exercise ability in pulmonary arterial hypertension

DOSE IN NORMAL RENAL FUNCTION <\/H3>ED: 25\u2013100 mg 0.5\u20134 hours before sexual intercourse (ideally, about 1 hour); no more than 1 dose per dayPulmonary arterial hypertension: 20 mg 3 times daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :666.7 (as citrate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :96<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <2<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :1\u20132<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :4\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Dose as in normal renal function10\u201330 Dose as in normal renal function ED: Initial dose 25 mg and increase if required
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function ED: Initial dose 25 mg and increase if required

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAlpha-blockers: enhanced hypotensive effect \u2013 avoid for 4 hours after sildenafil\n
  • Antivirals: ritonavir significantly increases sildenafil concentration \u2013 avoid concomitant use; concentration possibly increased by saquinavir, amprenavir, indinavir and nelfinavir \u2013 reduce dose of sildenafil; side effects possibly increased by atazanavirNicorandil: enhanced hypotensive effect \u2013 avoid concomitant use\n
  • Nitrates: enhanced hypotensive effect \u2013 absolutely contraindicated

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Dialysis is not expected to increase clearance as sildenafil is highly protein boundPatients should seek prompt medical advice if their erections last for more than 4 hoursRecommend use on non-dialysis days due to hypotension. In peritoneal dialysis, treatment with sildenafil is well toleratedAnecdotally it has been used at Guy\u2019s hospital, London for diabetic gastroparesis at a dose of 25 mg 3 times a dayThe use of sildenafil is potentially hazardous in patients with active coronary ischaemia, those with congestive heart failure, and those with complicated multi-drug antihypertensive therapy regimensIn 9 patients on maintenance haemodialysis, sildenafil 50 mg appeared to produce firmer erections and greater sexual satisfaction, but the effects were prolonged for up to 48 hours after administration.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of erectile dysfunction (ED) To increase exercise<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4680","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4680"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4680\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}