{"id":4673,"date":"2025-03-31T18:12:16","date_gmt":"2025-03-31T18:12:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/salbutamol-txt\/"},"modified":"2025-03-31T18:12:16","modified_gmt":"2025-03-31T18:12:16","slug":"salbutamol-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/salbutamol-txt\/","title":{"rendered":"salbutamol.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nBeta2-adrenoceptor agonist:Reversible airways disease

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 2\u20134 mg 3\u20134 times daily SC\/IM: 500 micrograms, repeated 4 hourly if necessaryIV: 250 micrograms slow bolus, repeated if requiredInfusion: start with 5 micrograms\/minute, adjust according to response, usually 3\u201320 micrograms\/minuteAerosol: 100\u2013200 micrograms (1\u20132 puffs) 4 times dailyPowder: 200\u2013400 micrograms 4 times dailyNebulisation: 2.5\u20135 mg 4 times daily, or more frequently

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :239.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :10<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 51\u201364<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :2\u20132.5<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :4\u20136\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsIncreased risk of hypokalaemia when diuretics, theophylline or large doses of corticosteroids are given with high doses of salbutamolAntihypertensives: acute hypotension with

    IV infusion <\/H4> of salbutamol and methyldopa

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV, SC, IM, oral, inhaled, nebulised

    Rate of Administration <\/H4>IV slow bolus;

    IV infusion <\/H4> 3\u201320 micrograms\/minute

    Comments<\/H4>Infusion: dilute 10 mL (10 mg) to 500 mL with sodium chloride 0.9% or glucose 5% (20 micrograms\/mL)Via syringe pump: dilute 10 mL (10 mg) to 50 mL with sodium chloride 0.9% or glucose 5% (200 micrograms\/mL)

    OTHER INFORMATION <\/H4>Monitor ECG\/BP\/pulse Nebulised salbutamol may be prescribed for hypokalaemic effect in acute hyperkalaemia (unlicensed).
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Beta2-adrenoceptor agonist:Reversible airways disease DOSE IN NORMAL RENAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4673","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4673"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4673\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}