{"id":4649,"date":"2025-03-31T18:12:15","date_gmt":"2025-03-31T18:12:15","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/raltitrexed-txt\/"},"modified":"2025-03-31T18:12:15","modified_gmt":"2025-03-31T18:12:15","slug":"raltitrexed-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/raltitrexed-txt\/","title":{"rendered":"raltitrexed.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nTreatment of colorectal cancer when fluorouracil and folinic acid cannot be used

DOSE IN NORMAL RENAL FUNCTION <\/H3>3 mg\/m2 every 3 weeks

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :458.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :93<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 40\u201350<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :548 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :198\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>55\u201365 Use 75% of the dose (2.25 mg\/m2) every 4 weeks25\u201354 Use 50% of the dose (1.5 mg\/m2) every 4 weeks<25 Avoid. See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR<25 mL\/min.<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in GFR<25 mL\/min.
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR<25 mL\/min.
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR<25 mL\/min.

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsFolic and folinic acid: impairs cytotoxic action

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>4 mL water for injection

    Route <\/H4>

    IV infusion <\/H4>

    Rate of Administration <\/H4>Over 15 minutes

    Comments<\/H4>Dilute in 50\u2013250 ml sodium chloride 0.9% or glucose 5%Stable for 24 hours at 2\u20138\u00b0C

    OTHER INFORMATION <\/H4>Doses above 3 mg\/m 2 have an increased incidence of life-threatening\/fatal toxicityIncreased risk of treatment-related toxicity if CrCl<65 mL\/minAnecdotal reports of using 30\u201340% of the dose every 4 weeks in patients with severe renal impairment and closely monitoring haematological parameters. Risk of severe and prolonged side effects \u2013 use if risk of not treating the patient outweighs the risk of adverse effectsNot metabolised. 40\u201350% is excreted unchanged in the urine and 15% of dose is excreted in the faeces over a 10-day period. Active tubular secretion may contribute to the renal excretion.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of colorectal cancer when fluorouracil and folinic<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4649","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4649"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4649\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}