{"id":4632,"date":"2025-03-31T18:12:14","date_gmt":"2025-03-31T18:12:14","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/primaxin-txt\/"},"modified":"2025-03-31T18:12:14","modified_gmt":"2025-03-31T18:12:14","slug":"primaxin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/primaxin-txt\/","title":{"rendered":"primaxin.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>IV: 1\u20134 g daily in 3\u20134 divided doses (as imipenem)IM, mild-moderate infections: 500\u2013750 mg every 12 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Imipenem: 317.4; cilastatin: 380.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Imipenem: 20; cilastatin: 40<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Imipenem: 20\u201370; cilastatin: 75<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Imipenem: 0.23; cilastatin: 0.22<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Imipenem: 1\/4; cilastatin: 1\/12

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>31\u201370 500 mg every 6\u20138 hours21\u201330 500 mg every 8\u201312 hours<20 250\u2013500 mg (or 3.5 mg\/kg whichever is lower) every 12 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR<20 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR<20 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR<20 mL\/minCAV\/VVhDialysed. 250 mg every 6 hours or 500 mg every 8 hours1CVVhd\/HDFDialysed. 250 mg every 6 hours or 500 mg every 6\u20138 hours1

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Ciclosporin: variable reports of increase\/ no change in ciclosporin levels, and of neurotoxicityConvulsions reported with concomitant administration of ganciclovir

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>250 mg with 50 mL, 500 mg with 100 mL sodium chloride 0.9% (in some units 500 mg with 50 mL)IM: 2 mL lidocaine 1%

    Route <\/H4>IM, IV peripherally or centrally (500 mg\/50 mL \u2013 given centrally)

    Rate of Administration <\/H4>250 or 500 mg dose over 20\u201330 minutes 1 g over 40\u201360 minutes

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Risk of adverse neurological effects, e.g. convulsions. Extreme caution required in patients with history of CNS diseaseCilastatin can accumulate in patients with impaired renal functionSodium content 1.72 mmol\/500 mg vial Imipenem is administered with cilastatin to prevent metabolism of imipenem within the kidneyNon-renal clearance in acute renal failure is less than in chronic renal failurePatients with GFR<5 mL\/min should not receive drug unless HD is started within 48 hours. Metabolised to inactive, nephrotoxic metabolites
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION IV:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4632","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4632"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4632\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}