{"id":4628,"date":"2025-03-31T18:12:14","date_gmt":"2025-03-31T18:12:14","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/potassium-chloride-txt\/"},"modified":"2025-03-31T18:12:14","modified_gmt":"2025-03-31T18:12:14","slug":"potassium-chloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/potassium-chloride-txt\/","title":{"rendered":"potassium chloride.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nHypokalaemia

DOSE IN NORMAL RENAL FUNCTION <\/H3>2\u20134 g (25\u201350 mmol) daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :74.6<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :N\/A<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : N\/A<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :N\/A<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :N\/A

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : According to response
  • 10 to 20 &nbsp &nbsp : According to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : According to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose according to response<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose according to response
  • HDF\/high flux &nbsp :Dialysed. Dose according to response
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose according to response

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsACE inhibitors and angiotensin- II antagonists: increased risk of hyperkalaemia\n
  • Ciclosporin: increased risk of hyperkalaemiaPotassium-sparing diuretics: increased risk of hyperkalaemia\n
  • Tacrolimus: increased risk of hyperkalaemia

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>Infusion up to 20 mmol potassium per hour except in extreme hypokalaemic emergency where some units give up to 40 mmol\/hour with cardiac monitoring

    Comments<\/H4>Give IV solution well diluted (not exceeding 40 mmol\/500 mL) for peripheral administrationMix IV solutions thoroughly to avoid layering effectSome units give more concentrated solution centrally: 100\u2013200 mmol\/100 mL sodium chloride 0.9% or glucose 5%, but at a rate not more than 20 mmol\/hourCardiac monitoring mandatory

    OTHER INFORMATION <\/H4>Potassium chloride injection MUST NOT be injected undilutedMonitor serum potassium levels Sando K: 12 mmol potassium per tablet Slow K: 8 mmol potassium per tablet Kay-Cee-L Syrup: 1 mmol potassium per mLPotassium chloride strong 15% injection: 20 mmol potassium \/10 mL
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Hypokalaemia DOSE IN NORMAL RENAL FUNCTION 2\u20134 g<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4628","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4628"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4628\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}