{"id":4617,"date":"2025-03-31T18:12:14","date_gmt":"2025-03-31T18:12:14","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/peginterferon-alfa-txt\/"},"modified":"2025-03-31T18:12:14","modified_gmt":"2025-03-31T18:12:14","slug":"peginterferon-alfa-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/peginterferon-alfa-txt\/","title":{"rendered":"peginterferon alfa.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nTreatment of chronic hepatitis B and C infection with or without ribavirin

DOSE IN NORMAL RENAL FUNCTION <\/H3>ViraferonPeg: 1.5 mcg\/kg once weekly in combination with ribavirin
Monotherapy: 0.5\u20131 mcg\/kg once weekly Pegasys: 180 mcg weekly

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :40 000<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 30<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.99<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :40\u201380\/increased by about 25\u201345%

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function. See \u2018Other Information\u2019
  • 10 to 20 &nbsp &nbsp : 135 mcg (Pegasys) once weekly. See \u2018Other Information\u2019
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 135 mcg (Pegasys) once weekly. See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsImmunosuppressants: (e.g. ciclosporin, tacrolimus, sirolimus) may have an antagonistic effectTheophylline: inhibits metabolism of theophylline (enhanced effect)

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>0.7 mL water for injection or pre-filled syringes

    Route <\/H4>SC

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Stable for 24 hours at 2\u20138\u00b0C after reconstitution

    OTHER INFORMATION <\/H4>Administer 12 hours after haemodialysis ViraferonPeg is contraindicated once GFR<50 mL\/min \u2013 monitor closely and reduce dose if requiredIn haemodialysis patients, 135 mcg Pegasys is equivalent to a 180 mcg dose in the general populationIn patients with CKD 5 undergoing haemodialysis there is a 25\u201345% reduction in clearance compared with patients with normal renal function
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of chronic hepatitis B and C infection<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4617","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4617"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4617\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}