{"id":4615,"date":"2025-03-31T18:12:14","date_gmt":"2025-03-31T18:12:14","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/paracetamol-and-codeine-phosphate-txt\/"},"modified":"2025-03-31T18:12:14","modified_gmt":"2025-03-31T18:12:14","slug":"paracetamol-and-codeine-phosphate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/paracetamol-and-codeine-phosphate-txt\/","title":{"rendered":"paracetamol and codeine phosphate.txt"},"content":{"rendered":"

paracetamol and codeine phosphate<\/h1>\n

CLINICAL USE <\/H3>
\nAnalgesic

DOSE IN NORMAL RENAL FUNCTION <\/H3>1\u20132 tablets up to 4 times a day

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Paracetamol: 151.2; codeine: 317.4 (codeine phosphate 406.4)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Paracetamol: 20\u201330; codeine: 7<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Paracetamol: <5; codeine: 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Paracetamol: 1\u20131.2; codeine: 3\u20134<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Paracetamol: 1\u20134\/Unchanged; codeine: 2.5\u20134\/13

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Available in 2 strengths: (1) 8\/500; 8 mg codeine phosphate\/500 mg paracetamol, (2) 30\/500; 30 mg codeine phosphate\/500 mg paracetamol30\/500 formulation: may cause drowsiness, due to increased cerebral sensitivity in patients with renal failure

    OTHER INFORMATION <\/H4>Effervescent formulations of Solpadol and Tylex (30\/500) should be avoided in renal impairment. They contain 16.9 mmol and 13.6 mmol sodium per tablet respectivelyIn renal impairment, opioid analgesics may produce a prolonged effect with increased cerebral sensitivityIncreased risk of constipation in ERF especially with 30\/500 preparation
    \n","protected":false},"excerpt":{"rendered":"

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