{"id":4605,"date":"2025-03-31T18:12:14","date_gmt":"2025-03-31T18:12:14","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/oseltamivir-txt\/"},"modified":"2025-03-31T18:12:14","modified_gmt":"2025-03-31T18:12:14","slug":"oseltamivir-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/oseltamivir-txt\/","title":{"rendered":"oseltamivir.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nTreatment and post-exposure prevention of influenza

DOSE IN NORMAL RENAL FUNCTION <\/H3>Treatment: 75 mg twice daily for 5 days Post-exposure prevention: 75 mg once daily for at least 10 days; up to 6 weeks if epidemic in community

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :410.4 (as phosphate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :42 (3 as carboxylate) <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Negligible (99% excreted as carboxylate metabolite in urine)<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.3\u20130.4<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1\u20133, (6\u201310 as metabolite)\/ >20

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Dose as in normal renal function10\u201330 Treatment: 75 mg once daily or 30 mg twice daily Prophylaxis: 75 mg every 48 hours or 30 mg once daily
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Treatment: 30 mg once off dose Prophylaxis: 30 mg every 10 days1 See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Treatment: 30 mg stat; prophylaxis: 30 mg weekly2<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Treatment: 30 mg stat; prophylaxis: 30 mg after alternate dialysis sessions2
  • HDF\/high flux &nbsp :Dialysed. Treatment: 30 mg stat; prophylaxis: 30 mg after alternate dialysis sessions2
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Oseltamivir is a prodrug; extensively metabolised in the liver to the active carboxylate metaboliteAt least 75% of the oral dose reaches the systemic circulation as the carboxylateAll the active metabolite is excreted in the urineA lower dose is required in severe renal disease due to the active metabolite accumulating
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment and post-exposure prevention of influenza DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4605","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4605"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4605\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}