{"id":4580,"date":"2025-03-31T18:12:13","date_gmt":"2025-03-31T18:12:13","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/netilmicin-txt\/"},"modified":"2025-03-31T18:12:13","modified_gmt":"2025-03-31T18:12:13","slug":"netilmicin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/netilmicin-txt\/","title":{"rendered":"netilmicin.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>IM, IV: 4\u20137.5 mg\/kg daily, as a single daily dose or in divided doses every 8 or 12 hoursUrinary tract infection: 150 mg daily for 5 days

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :1441.6 (as sulphate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :<5<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 80<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.16\u20130.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u20132.5\/35\u201372

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : 4\u20137.5 mg\/kg once daily. Monitor levels
  • 10 to 20 &nbsp &nbsp : 3\u20134 mg\/kg once daily. Monitor levels
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 2 mg\/kg once daily. Monitor levels

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. IV: 2 mg\/kg on alternate daysIP: 7.5\u201310 mg\/L per exchange. Monitor levels<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Administer 2 mg\/kg at the end of each dialysis session. Monitor levels
  • HDF\/high flux &nbsp :Dialysed. Administer 2 mg\/kg at the end of each dialysis session. Monitor levels
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201320 mL\/min. Monitor levels

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsBotulinum toxin: neuromuscular block enhanced (risk of toxicity)\n
  • Ciclosporin: increased risk of nephrotoxicityCytotoxics: increased risk of nephrotoxicity and possibly of ototoxicity with platinum compounds\n
  • Diuretics: increased risk of ototoxicity with loop diureticsMuscle relaxants: effects of non- depolarising muscle relaxants and suxamethonium enhancedParasympathomimetics: antagonism of effect of neostigmine and pyridostigmine\n
  • Tacrolimus: increased risk of nephrotoxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IM, IP, IV bolus or infusion

    Rate of Administration <\/H4>IV bolus: Administer over 3\u20135 minutes

    IV infusion <\/H4>: Administer over 0.5\u20132 hours

    Comments<\/H4>Add to 50\u2013200 mL of sterile water for injection, sodium chloride 0.9%, glucose 5% or 10%IM and IV dose are identical. Calculate on mg\/kg lean body weight, or actual weight, whichever is lower

    OTHER INFORMATION <\/H4>Netilmicin serum concentrations should be monitored and used for basis of dosage adjustment, otherwise follow guidelines in the SPC according to serum creatinine\/creatinine clearanceOnce-daily administration of netilmicin may lead to transient peak concentrations of 20\u201330 micrograms\/mL. Other dosage regimens will result in peak levels not exceeding 12 micrograms\/mL. Prolonged levels above 16 micrograms\/mL should be avoided. If trough levels are monitored they will usually be 3 micrograms\/mL or less with the recommended dosage. Increasing trough concentrations above 4 micrograms\/mL should be avoided.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION IM,<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4580","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4580"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4580\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}