{"id":4554,"date":"2025-03-31T18:12:12","date_gmt":"2025-03-31T18:12:12","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/methadone-hydrochloride-txt\/"},"modified":"2025-03-31T18:12:12","modified_gmt":"2025-03-31T18:12:12","slug":"methadone-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/methadone-hydrochloride-txt\/","title":{"rendered":"methadone hydrochloride.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nTreatment of opioid drug addiction Analgesic for moderate to severe pain

DOSE IN NORMAL RENAL FUNCTION <\/H3>Opioid addiction: 10\u201340 mg per day, increasing by 10 mg per day until there are no signs of withdrawal or intoxication; reduce graduallyAnalgesia: 5\u201310 mg every 6\u20138 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :346.9<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :60\u201390<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 15\u201360<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 3\u20136<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :13\u201347\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50% of normal dose, and titrate according to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antidepressants: concentration possibly increased by fluvoxamine; possible CNS excitation or depression with MAOIs and moclobemide \u2013 avoid concomitant use; possibly increased sedative effects with tricyclics\n
  • Anti-epileptics: concentration reduced by carbamazepine and phenytoin\n
  • Antifungals: concentration increased by voriconazole \u2013 may need to reduce methadone dose\n
  • Antivirals: methadone possibly increases concentration of zidovudine; concentration reduced by amprenavir, efavirenz, nelfinavir and ritonavir; concentration possibly reduced by abacavir and nevirapine\n
  • Atomoxetine: increased risk of ventricular arrhythmiasSodium oxybate: enhanced effect of sodium oxybate \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IM, SC, oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Methadone is probably not suitable to be used as an analgesic for patients with severe renal impairment

    OTHER INFORMATION <\/H4>Overdosage with methadone can be reversed using naloxoneRisk of QT interval prolongation especially with high doses and concomitant risk factors
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of opioid drug addiction Analgesic for moderate<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4554","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4554"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4554\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}